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Eucommia and Rehmannia Combination is You Gui Wan (Restore the Right Pill), first published in 1624 in The Collected Treatises of Zhang Jing Yue. In Chinese physiology, Yang is viewed as stored in the right Kidney and is also known as the Gate of Vitality, and You Gui Wan is an unmitigated tonic of Kidney Yang and Essence. It draws inspiration, however, from the more moderate Rehmannia Eight Combination (Ba Wei Di Huang Wan) of a thousand years earlier by using several of the same herbs.

The use of prepared Aconite root, Chinese cinnamon bark, prepared Rehmannia root, Asiatic cornelian cherry and Chinese yam rhizome is drawn from Rehmannia Eight Combination. Prepared Aconite root and Chinese cinnamon bark warm the Kidney Yang, while prepared Rehmannia root, Asiatic cornelian cherry and Chinese yam rhizome tonify Yin and Blood and preserve Essence.

Eucommia bark tonifies Kidney Yang. Dong quai root assists with the nourishment of Liver Blood, while Lycium fruit tonifies Liver and Kidney Yin to relieve occasional low back and knees weakness and stiffness. Psoralea fruit has been added to the original version of Eucommia and Rehmannia Combination, and together with Chinese dodder seed, it tonifies Kidney Yang.